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John R. Fischer, Senior Reporter | May 18, 2020
The team collected cerebrospinal fluid (CSF) samples in five of 10 patients with cortical signal abnormalities. Four showed elevated protein levels; cell counts, glucal levels, IgG index, and albumin were normal, while RT-PCR for both herpes simplex virus and SARS-CoV-2 were negative. Fifteen cases showed no COVID-19-related or acute intracranial findings during MR exams, though two samples of CSF from the group showed elevated protein levels.
The authors claim that the study may help increase awareness of a possible relationship between SARS-CoV-2 and neurological abnormalities in infected patients, especially those in the ICU.
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They warn, however, that comorbid conditions must be accounted for as confounding factors in the neurological abnormalities found, including diabetes mellitus, prolonged ICU stays, and respiratory distress with hypoxia. They also note the difficulty in establishing a concise cause-and-effect relationship between COVID-19 and MR results without more specific CSF findings, meaning that more research is required.
The findings were published in
Radiology.
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