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Molecular Imaging Homepage

Louisiana getting $14 million Center for Molecular Imaging and Therapy Increasing research opportunities, collaboration and radiopharmaceuticals

DOE transfers land to Coquí Pharma for isotope production facility Will be used primarily to produce Mo-99

Amyloid PET scans help with Alzheimer's clinical management New insights from the 11,000 patient IDEAS study

United Imaging's total-body PET scanner shows promise in four new studies Faster scans, lower dose and 'a level of detail never seen in PET'

NorthStar buys IBA electron accelerators for Mo-99 production Will increase production capacity and efficiencies

RadioMedix and Vect-Horus to develop brain theranostic agent for brain cancer Provide diagnosis and treatment of Glioblastoma Multiforme (GBM)

NIH awards $1.8 million to Magnetic Insight for neurovascular MPI Detects magnetic nanoparticle tracers, enables deep-tissue imaging

DOE to cut Moly-99 deals with four US firms Could be as much as $15 million per company, with partners matching awarded amounts

Women's brains appear three years younger than men's at the same age: PET study A machine-learning algorithm assisted with the analysis

Dennis Durmis MITA names chair of board of directors

An experimental form of PET
imaging has uncovered elevated
amounts of abnormal tau protein in
live subjects with symptoms
of CTE

PET uncovers abnormal tau deposits associated with CTE in live subjects

por John R. Fischer , Staff Reporter
An experimental form of PET imaging may potentially enable the diagnosis of chronic traumatic encephalopathy in live subjects at some point in the future, according to a new study.

Researchers from Boston and Arizona performed flortaucipir PET scans on a number of living former National Football League players, finding elevated amounts of abnormal tau protein in their brains, in regions affected by CTE.

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"Currently if is not possible to assess abnormal tau accumulation in the brain during life. We must perform an autopsy of the brain and look for the abnormal tau," Charles H. Adler, professor of neurology at Mayo Clinic College of Medicine at the Mayo Clinic Arizona, told HCB News. "That is why developing the PET scan is so critical to the field."

A neurodegenerative disease, CTE is associated with a history of repetitive head impacts, including those that may or may not be associated with concussion symptoms experienced by American football players. Its diagnosis can only take place following the death of a person, through a neuropathological exam. The build-up of an abnormal form of tau protein in a specific pattern in the brain is the hallmark finding.

The researchers applied experimental flortaucipir PET scans to evaluate tau deposition in the brains of 26 living former NFL players between the ages of 40 and 69, who experienced cognitive, mood and behavior symptoms. They also assessed 31 men of the same ages without symptoms or histories of traumatic brain injuries.

Tau PET levels were found to be significantly higher among the players, compared to the control group, with the tau found in parts of the brain that have been confirmed in post-mortem cases to be areas impacted by neuropathologically diagnosed CTE.

The study authors also performed FDA-approved florbetapir PET scanning to assess amyloid plaque deposition, and found no difference between both groups, suggesting that symptoms experienced by athletes who have suffered repetitive head injuries in the past do not signal the onset of Alzheimer’s disease, another neurological condition characterized by the presence of tau and amyloid accumulation. Past diagnoses of CTE support this assessment, with the disease based, in part, on the pattern of tau deposition and a relative lack of Amyloid plaques.

"There is an interest in tau PET tracers with improved ability to detect the tau PET changes associated with not only AD, but with the tau pathology associated with certain other neurodegenerative diseases and with CTE," study co-author, Eric Reiman, executive director of Banner Alzheimer’s Institute, told HCB News.
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