PHILADELPHIA, December 7, 2015 - Uncontrolled epilepsy affects more than 1.2 million Americans, often requiring a series of trials and errors to identify effective drug combinations. Continuous, long-term EEG data could streamline this process by revealing the full picture of a patient's seizure activity, but this would require a costly and inconvenient hospital stay.

An array of personal monitoring devices - including three to be unveiled at the American Epilepsy Society's (AES) 69th Annual Meeting* - offer biometric recording technology that could allow patients to monitor clinical and subclinical seizure activity in the everyday home environment and get advance warning before a seizure strikes.

Researchers from the University of Utah and Epitel Inc., (abstract 2.158) describe an inexpensive, disposable and discreet seizure-monitoring device called the EEG PatchTM. According to the authors, the patch is waterproof and relies on two electrodes to record EEG data during all aspects of everyday life, including bathing, sports and sleep. The device can operate for seven days on a single charge, and data can be downloaded anytime for review in the standard European Data Format. An epileptologist must position the device on the scalp at a known seizure-prone area of the brain identified by a traditional wired EEG.

"Armed with seven-day, location-specific EEG data, an epileptologist will have a robust record of quantitative seizure counts to better treat patients, revolutionizing therapy," says author Mark Lehmkuhle, Ph.D., an assistant professor of neurosurgery at the University of Utah.

In a second study, (abstract 3.088) a device capable of detecting and recording generalized tonic-clonic seizures (GTCS), known as the Brain Sentinel® GTC Seizure Detection and Warning System, is described by researchers from Brain Sentinel and the Medical University of South Carolina, Thomas Jefferson University, the Cleveland Clinic, the Mayo Clinic, Children's Hospital of Philadelphia, Emory University, the University of Pennsylvania, NYU Comprehensive Epilepsy Center, University of Minnesota and the Texas Health Research & Education Institute.

The authors report the results of a Phase III, double-blind, prospective multicenter study of the Brain Sentinel® System, which continuously detects and records surface electromyography (sEMG) and audio data from a device worn on the biceps muscle. Their findings demonstrate that the System can detect seizure activity with 100 percent sensitivity and a very low rate of false detection, compared with video EEG detection in epilepsy monitoring units at 11 level IV epilepsy centers in the U.S. According to the authors, the system sends alerts within an average of a few seconds after the onset of the GTCS. The Brain Sentinel® System is currently under FDA review for market clearance.

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