First patient treated with focused ultrasound in new Parkinson's disease trial

por Lauren Dubinsky, Senior Reporter | May 03, 2018
Alzheimers/Neurology Ultrasound
Can it alleviate major motor symptoms?
A trial investigating the use of focused ultrasound to treat the major motor symptoms of Parkinson’s disease recently treated the first patient at NewYork-Presbyterian/Weill Cornell Medical Center.

The trial will ultimately recruit more than 100 patients with advanced, medication-refractory Parkinson’s disease.

“[We] hope that the results will help us and the FDA determine whether this experimental therapy can be a safe and effective noninvasive option for patients who are having difficulty with medical therapy,” Dr. Michael Kaplitt, neurological surgeon at the medical center, said in a statement.
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Patients are also currently being enrolled at the University of Maryland Medical Center and The Ohio State University Wexner Medical Center. Additional sites are expected to participate as well.

The patients will be treated with Insightec’s Exablate Neuro device, which received FDA approval for essential tremor in 2016. They will then be followed for one year to determine the treatment’s overall effectiveness and durability.

This trial is on the heels of a pilot study that included 31 Parkinson’s disease patients treated with focused ultrasound at six sites in the U.S. and Canada, and the results are awaiting publication. Another pilot trial published in JAMA Neurology in November studied the use of focused ultrasound to treat tremor-dominant Parkinson’s.

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