July 27, 2016, Elsevier Health Sciences -- Although active surveillance, or watchful waiting, for patients with low risk prostate cancer has become an increasingly acceptable strategy for disease management, many men opt for definitive therapies such as radical prostatectomy or radiation therapy. A new study of more than 2,200 patients with low risk prostate cancer in an ethnically and economically diverse population revealed that ethnicity influences this decision. The results, published in The Journal of Urology®, indicate that black men may be more likely than white men to begin active treatment independent of followup clinical measures, a finding that suggests greater attention to race/ethnicity is needed.

"A primary reason that we examined whether sociodemographic and clinical factors predicted switching to active treatment was that studies have primarily been performed in non-ethnically diverse populations," explained co-principal investigator Scott P. Kelly, PhD, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC. "We wanted to determine whether observational management like active surveillance is underused in minority populations, particularly within the framework of an equal access health care system. This is one of the few groups studied with sufficient sample sizes to examine whether the associations of clinical triggers for beginning active treatment varied by sociodemographic factors."

The study included patients who had been diagnosed with low risk prostate cancer between 2004 and 2012 at Kaiser Permanente Northern California. They did not receive any treatment within the first year of diagnosis and had at least two years of followup. "Because Kaiser Permanente Northern California is a large, integrated health system covering a diverse population, it was possible to independently assess ethnic and economic influences on treatment choices," said Stephen Van Den Eeden, PhD, co-principal investigator for the study and lead researcher at the Kaiser Permanente Division of Research, Oakland, CA. "Over 31% of patients studied were from minority populations."

Non-Hispanic black men were slightly more likely to begin active treatment than non-Hispanic white men, independent of their status at the beginning of the study and followup clinical measures. Among men who remained on observation, non-Hispanic black men were re-biopsied within 24 months of diagnosis at a slightly lower rate than non-Hispanic white men.

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